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Malin Celander

Professor, Zoophysiology

Tel: 46(0)31-786 36 93 | malin.celander@bioenv.gu.se

Research interests

I head the Cytochrome P450 (CYP) lab, and our research focuses on  drug-interactions in fish.

Academic career 

  • 2005 Professor in Zoophysiology, University of Gothenburg, Sweden (current position)
  • 2000 Docent (Associate Professor), University of Gothenburg
  • 1997 Assistant Professor in Experimental Biology, University of Gothenburg
  • 1994-97 Post-doc at Biology Department, Woods Hole Oceanographic Institution, MA, USA 
  • 1994 PhD in Zoophysiology, University of Gothenburg
  • 1978 BSc in Chemistry, University of Gothenburg

Publications

Review

Celander, M. C. (2011). Cocktail-effects on biomarker responses in fish. Aquatic Toxicology. in press Nr. 146480

Original Research Papers from this millennium

Celander M.C., Goldstone J.V., Denslow N.D., Iguchi T., Kille P., Meyerhoff R.D., Smith B.A., Hutchinson T.H. and Wheeler J.R. 2011. Species extrapolation for the 21st century. Environ. Toxicol. Chem. 30 (1) s. 52-63. Nr. 112888.

Gräns J., Wassmur B. and Celander M.C. 2010. One-way inhibiting cross-talk between arylhydrocarbon receptor (AhR) activation and estrogen receptor (ER) signalling in primary cultures of rainbow trout hepatocytes. Aquat. Toxicol. 100, 263-270.

Kachanopas-Barnette P., Mokkongpai P., Wassmur B., Celander M. and Sawangwong P. 2010. Molecular characterization of cytochrome P450 1A (CYP1A) in Asian sea bass (Lates calcalifer Bloch) and its application as a biomarker in the Gulf of Thailand. Asian J. Water Environ. Pollution. 7, 43-51.

Wassmur B., Gräns J., Kling P. and Celander M.C. 2010. Interactions of pharmaceuticals and other xenobiotics on hepatic pregnane X receptor and cytochrome P450 3A signaling pathway in rainbow trout (Oncorhynchus mykiss). Aquat. Toxicol. 100, 91-100.

Hasselberg L. Wassmur B. and Celander M.C. 2008. Ketoconazole, an antifungal imidazole, increases the sensitivity of rainbow trout to 17α-ethynylestradiol exposure. Aquat. Toxicol. 86, 256-264.

Lennquist A., Celander M.C. and Förlin L. 2008. Effects of medetomidine on hepatic EROD activity in three species of fish. Ecotoxicol. Environm. Safety. 69, 74-9

Sturve J., Hasselberg L., Fälth H., Celander M. and Förlin L. 2006. Effects of North Sea Oil and alkylphenols on biomarker responses in juvenile Atlantic cod (Gadus morhua). Aquatic Toxicol. 78S, S73-S78.

Hasselberg L. Grøsvik B.-E., Goksøyr A. and Celander M.C. 2005. Interactions between xenoestrogens and ketoconazole on CYP1A and CYP3A in juvenile Atlantic cod (Gadus morhua). Comp. Hepatol. 4:2

James M.O., Lou Z., Rowland-Faux L., Celander M. 2005. Regulation, expression and activity of CYP3A in intestinal microsomes of the channel catfish. Aquat. Toxicol. 72, 361-371.

Hasselberg L., Meier S., Hegelund T., Svardal A. and Celander M. 2004. Effects of alkylphenols and 17β-estradiol on CYP1A and CYP3A in adult Atlantic cod (Gadus morhua). Aquat. Toxicol. 67, 303-313.

Hegelund T., Ottosson K., Tomberg P., Rådinger M. and Celander M.C. 2004. Effects of ketoconazole on CYP1A and CYP3A in rainbow trout and killifish. Environ. Toxicol. Chem. 23, 1326-1334.

Stephensen E., Adolfsson-Erici M., Celander M., Hulander M., Parkkonen J., Hegelund T., Sturve J., Hasselberg L., Bengtsson M. and Förlin L. 2004. Biomarker responses and chemical analyses in fish indicate leakage of PAH and other compounds from car tire rubber. Environ. Toxicol. Chem. 22, 2926-2931.

Hegelund T. and Celander M.C. 2003. Hepatic versus extrahepatic expression of CYP3A30 and CYP3A56 in adult killifish (Fundulus heteroclitus). Aquatic Toxicol. 64, 277-291.

McArthur A.G., Hegelund T., Cox R.L., Stegeman J.J., Liljenberg M., Olsson U. Sundberg P. and Celander M.C. 2003. Phylogenetic analysis of the CYP3 gene family. J. Mol. Evol. 57, 200-211.

Jørgensen, E.H., Celander, M., Goksøyr, A. and Iwata, M. 2001. The effect of stress on toxicant-dependent cytochrom P450 enzyme responses in the Arctic charr (Salvenius alpinus). Environ. Toxicol. Chem. 20, 2523-2529.

Celander, M.C., Moore, M.J. and Stegeman, J.J. 2000. Cellular localization of CYP3A-like proteins in hepatic and extrahepatic tissues from pilot whale (Globicephalia melas). Environ. Toxicol. Pharmacol. 8, 245-253.

Minireview

Malin Celander and John Stegeman. Evolution of Drug-metabolizing CYP genes. SCREENING trends in drug discovery. 8 (2007) 34-5.

Bookchapters

Malin Celander. Impact of stress in animal toxicology. In: Stress Physiology in Animals. Ed. Paul H.M. Balm. Sheffield Academic Press. Sheffield, UK., 1999. Chapter 7, pp. 247-279. ISBN 1 85075 908 1.

McClelland-Green, P., Celander, M. and Oberdörster, E. In: Reptile Toxicology. Chapter 5: Hepatic and Renal Toxicology. Eds. Susan Gardner and Eva Oberdörster. Taylor and Francis publisher. Taylor and Francis publisher. Chapter 5, pp 123-148. ISBN 0-8493-2715-6.

D. Schlenk, S. George, M. James, P. van den Hurk, K. Willett, S. Kullman, M. Celander, and E. Gallagher. Chapter 4. Biotransformations In: The Toxicology of Fishes. Eds. R. Di Giulio and D. Hinton. 2008. Taylor and Francis Publishers, Washington DC. pp. 153-234.



Page Manager: Sven Toresson|Last update: 5/17/2012
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